See previous publications on research and development by Our Team.

2021

Eric Leblanc, Fuqiang Ban, Ayse Derya Cavga, Sam Lawn, Chia-Chi Flora Huang, Sankar Mohan, Matthew E. K. Chang, Mark R. Flory, Fariba Ghaidi, Shreyas Lingadahalli, Gang Chen, Ivan Pak Lok Yu, Hélène Morin, Nada Lallous, Martin E. Gleave, Hisham Mohammed, Robert N. Young, Paul S. Rennie, Nathan A. Lack, and Artem Cherkasov. Development of 2-(5,6,7-Trifluoro-1H-Indol-3-yl)-quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Prostate Cancer J Med Chem 2021

Fuqiang Ban1, Eric Leblanc1, Ayse Derya Cavga, Chia-Chi Flora Huang, Mark R. Flory, Fan Zhang,Matthew E. K. Chang, Hélène Morin, Nada Lallous, Kriti Singh, Martin E. Gleave, Hisham Mohammed, Paul S. Rennie, Nathan A. Lack and Artem Cherkasov .Development of an Androgen Receptor Inhibitor Targeting the N-Terminal Domain of Androgen Receptor for Treatment of Castration Resistant Prostate Cancer Cancers. 2021.

2020

Laura A Baker, Holly Holliday, Daniel Roden, Christoph Krisp, Sunny Z Wu, Simon Junankar, Aurelien A Serandour, Hisham Mohammed, Radhika Nair, Geetha Sankaranarayanan, Andrew MK Law, Andrea McFarland, Peter T Simpson, Sunil Lakhani, Eoin Dodson, Christina Selinger, Lyndal Anderson, Goli Samimi, Neville F Hacker, Elgene Lim, Christopher J Ormandy, Matthew J Naylor, Kaylene Simpson, Iva Nikolic, Sandra O’Toole, Warren Kaplan, Mark J Cowley, Jason S Carroll, Mark Molloy, & Alexander Swarbrick. Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer. Breast Cancer Research. 2020.

Neel Shah, Nikolas Kesten, Alba Font-Tello, Matthew EK Chang, Raga Vadhi, Klothilda Lim, Mark R Flory, Paloma Cejas, Hisham Mohammed, Henry W Long, & Myles Brown. ERG-mediated coregulator complex formation maintains androgen receptor signaling in prostate cancer. Cancer Research. 2020.

Theodore P Braun, Joseph Estabrook, Daniel J Coleman, Zachary Schonrock, Brittany M Smith, Trevor Enright, Cody Coblentz, Rowan Callahan, Hisham Mohammed, Brian J Druker, Theresa Lusardi, & Julia E Maxson. ASXL1 Directs Neutrophilic Differentiation via Modulation of MYC and RNA Polymerase II. BioRxiv. 2020.

Athina Giannoudis, Mohammed I Malki, Hisham Mohammed, Bharath Rudraraju, Suraj Menon, Simak Ali, Jason S Carroll, & Carlo Palmieri. The regulatory role of activating transcription factor-2 (ATF2) in modulating tamoxifen resistance in estrogen-receptor positive breast cancer. Cancer Research. 2020.

2019

Ricard Argelaguet*, Stephen Clark*Hisham Mohammed*, Carine Stapel, Christel Krueger, Chantriolnt-Andreas Kapourani, Yunlong Xiang, Courtney Hanna, Sebastien Smallwood, Ximena Ibarra-Soria, Florian Buettner, Guido Sanguinetti, Felix Krueger, Wei Xie, Peter Rugg-Gunn, Gavin Kelsey,Wendy Dean, Jennifer Nichols, Oliver Stegle, John Marioni, & Wolf Reik. fillefffr Multi-omics profiling of mouse gastrulation at single-cell resolution. Nature. 2019.

Michael Chiang, Davide Michieletto, Chris A Brackley, Nattaphong Rattanavirotkul, Hisham Mohammed, Davide Marenduzzo, & Tamir Chandra. Polymer Modeling predicts chromosome reorganization in senescence. Cell Reports. 2019.

Tobias Messmer, Ferdinand von Meyenn, Aurora Savino, Fátima Santos, Hisham Mohammed, Aaron Tin Long Lun, John C Marioni, & Wolf Reik. Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution. Cell Reports. 2019.

2018

Hisham Mohammed*, Aurelien Serandour*, Ahmad Miremadi, Klaas Mulder, & Jason Carroll. TRPS1 regulates estrogen receptor binding and histone acetylation at enhancers. Oncogene. 2018.

Thorsten Boroviak, Giuliano G Stirparo, Sabine Dietmann, Irene Hernando-Herraez, Hisham Mohammed, Wolf Reik, Austin Smith, Erika Sasaki, Jennifer Nichols, & Paul Bertone. Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development. Development. 2018.

Anne Y. Warren , Charlie E. Massie, Kate Watt , Katarina Luko, Folake Orafidiya, Luke A. Selth, Hisham Mohammed, Brinder Chohan, Suraj Menon, Ajoeb Baridi, Wanfeng Zhao, Carles Escrui, Clive D’Santos, Xiaoping Yang, Chris Taylor, Arham Qureshi, Kate Watt, Vincent R. Zecchini, Greg L. Shaw, Scott M. Dehm, Ian G. Mills, Jason S. Carroll, Wayne D. Tilley, Iain J. McEwan, Aria Baniahmad and David E. Neal, & Mohammad Asim. A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer. Oncogene. 2018.

Margaret M Centenera, Theresa E Hickey, Shalini Jindal, Natalie K Ryan, Preethi Ravindranathan, Hisham Mohammed, Jessica L Robinson, Matthew J Schiewer, Shihong Ma, Payal Kapur, Peter D Sutherland, Clive E Hoffmann, Claus G Roehrborn, Leonard G Gomella, Jason S Carroll, Stephen N Birrell, Karen E Knudsen, Ganesh V Raj, Lisa M Butler, & Wayne D Tilley. A patient derived explant (PDE) model of hormone dependent cancer. Molecular Oncology. 2018.

Steffen Rulands, Heather J. Lee, Stephen J. Clark, Christof Angermueller, Sébastien A. Smallwood, Felix Krueger, Hisham Mohammed, Wendy Dean, Jennifer Nichols, Peter Rugg-Gunn, Gavin Kelsey, Oliver Stegle, Benjamin D. Simons, & Wolf Reik. Genome scale oscillations in DNA methylation during exit from pluripotency. Cell Systems. 2018.

2017

Hisham Mohammed*, Irene Herraez*, Aurora Savino*, Antonio Scialdone, Iain Macauley, Carla Mulas, Simon Andrews, Tamir Chandra, Thierry Voet, Shankar Srinivas, Wendy Dean, Jenny Nichols, John Marioni & Wolf Reik. Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation. Cell Reports. 2017.

Rinath Jeselsohn, MacIntosh Cornwell, Matthew Pun, Gilles Buchwalter, Mai Nguyen, Clyde Bango, Ying Huang, Yanan Kuang, Cloud Paweletz, Xiaoyong Fu, Simone Detre, Andrew Dodson, Hisham Mohammed, Jason Carroll, Michaela Bowden, Prakash Rao, Henry Long, Fugen Li, Mitch Dowsett, Rachel Schiff, & Myles Brown. The embryonic transcription factor SOX9 drives breast cancer endocrine resistance. PNAS. 2017.

2016

Hisham Mohammed*, Christopher Taylor, Gordon Brown, Eva Papachristou, Jason Carroll, & Clive D’Santos*. Rapid Immunoprecipitation and Mass Spectrometry of Endogenous Proteins. Nature Protocols. 2016.

Liis Uusküla-Reimand, Huayun Hou, Payman Samavarchi-Tehrani, Matteo Vietri Rudan, Minggao Liang, Alejandra Medina-Rivera, Hisham Mohammed, Dominic Schmidt, Petra Schwalie, Edwin J. Young, Jüri Reimand, Suzana Hadjur, Anne-Claude Gingras, & Michael D. Wilson. Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders. Genome Biology. 2016.

Shaokun Shu, Charles Lin, Housheng Hansen He, Ernest Doherty, Jonathan Brown, Hisham Mohammed, Clive D’Santos, Michael McKeown, Christopher Ott, Jun Qi, Min Ni, Prakash Rao, Melissa Duarte, Cheng-Ming Chiang, Lars Anders, Richard A. Young, Jason Carroll, Henry Long, Myles Brown, Shirley. X. Liu, Clifford A. Meyer, James E. Bradner, & Kornelia Polyak. Response and resistance to BET bromodomain inhibitors in triple negative breast cancer. Nature. 2016.

Mohammed Asim, Anne Warren, Luke Selth, Heather Zecchini, Ajoeb Baridi, Suraj Menon, Bassetti Madhu, Carlos Escrio, Scott Lyons, Vincent Zecchini, Greg Shaw, Wiebke Hessenkemper, Roslin Russell, Hisham Mohammed, Arham Qureshi, Rouchelle Sriranjan, Niki Stefanos, Andy G. Lynch, Elena Grigorenko, Alastair Lamb, Rory Stark, Paul Rennie, Aria Baniahmad, Jason Carroll, John Griffiths, Simon Tavaré, Iain McEwan, Ian Mills, Wayne Tilley, & David Neal. Choline kinase alpha is a novel androgen receptor chaperone and prostate cancer therapeutic target. Journal of the National Cancer Institute. 2016.

2015

Hisham Mohammed, Alasdair Russell, Rory Stark, Oscar M. Rueda, Theresa E. Hickey, Suraj Menon, Amel Saadi, Ganesh V. Raj, Gordon D. Brown, Clive D’Santos, Jessica L. L. Robinson, Charles M. Perou, Aurelien A. Serandour, Rosalind Launchbury, John Stingl, Carlos Caldas, Wayne D. Tilley, & Jason S. Carroll. Progesterone receptor redirects ERα chromatin binding in breast cancer to elicit good clinical outcome. Nature. 2015.

Clive D’Santos, Jason S. Carroll, & Hisham Mohammed*. RIME proteomics of Estrogen and Progesterone receptors in breast cancer. Data in brief. 2015.

Paulina A. Latos, Angela Goncalves, David Oxley, Hisham Mohammed, Ernest Turro, & Myriam Hemberger. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of Trophoblast Stem Cells. Nature Communications. 2015.

2014

Jangal M, Courture JP, Bianco S, Magnani L, Hisham Mohammed, & Gévry N. The Transcriptional co-repressor TLE3 suppresses basal signaling on a subset of estrogen receptor α target genesNucleic acids research. 2014. 

Zongling Ji, Hisham Mohammed, Aaron Webber, Jenna Ridsdale, Namshik Han, Jason S. Carroll, & Andrew D. Sharrocks. The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex. Nucleic acids research. 2014.

2013

Hisham Mohammed, Clive D’Santos, Aurelien A. Serandour, H. Raza Ali, Gordon. D. Brown, Alan Atkins, Oscar M. Rueda, Kelly A Holmes, Vasiliki Theodorcou, Wilbert Zwart, Jessica L. L. Robinson, Amel Saadi, Caryn S. Ross-Innes, Suet-Feung Chin, Suraj Menon, John Stingl, Carlo Palmieri, Carlos Caldas, & Jason S. Carroll. Endogenous purification reveals GREB1 as a Key Estrogen Receptor regulatory factor. Cell Reports. 2013. 

Hisham Mohammed and Jason S. Carroll. Approaches for assessing and discovering protein interactions in cancer. Molecular Cancer Research. 2013.

2012

B. Basu, P.Correa de Sampaio, Hisham Mohammed, M. Fogarai, P. Corrie, N.A. Watkins, P.A. Smethurst, W.R. English, W.H. Ouwenhand, & G. Murphy. Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domain. Int J Biochem Cell Biol. 2012.

2011

L. Y. Pang, M. Scott, R. L. Hayward, Hisham Mohammed, C. B. Whitelaw, G. C. Smith, & Ted R. Hupp. p21(WAF1) is component of a positive feedback loop that maintains the p53 transcriptional program. Cell Cycle. 2011.

filler